Mitogenic activity of influenza virus and haemagglutinin
Identifieur interne : 002432 ( Main/Exploration ); précédent : 002431; suivant : 002433Mitogenic activity of influenza virus and haemagglutinin
Auteurs : E. Margot Anders [Australie] ; Anthony A. Scalzo [Australie] ; David O. White [Australie]Source :
- Vaccine [ 0264-410X ] ; 1985.
English descriptors
- Teeft :
- Accessory cell, Alan hampson, Antigen expression, Antithymocyte serum, Cell mitogenesis, Cell mitogens, Cell surface, Commonwealth serum laboratories, Cona, Culture medium, Goat serum, Haemagglutinin, Haplotype, Herpes simplex virus, Immune response, Influenza, Influenza virus, Influenza viruses, Lymphocyte, Lymphocyte mitogens, Macrophage, Major histocompatibility, Mitogen, Mitogenesis, Mitogenic, Mitogenic activity, Mitogenic response, Mitogenic responses, Mitogenicity, Monoclonal antibody, Murine spleen cells, Normal spleen cells, Nylon wool columns, Poor responders, Proliferative response, Sindbis virus, Spleen, Spleen cells, Stimulation index, Unseparated spleen cells, Vesicular stomatitis virus, Virus.
Abstract
Abstract: Influenza A viruses behave as T cell-independent B cell mitogens in vitro. The magnitude of the proliferation induced varies with the haemagglutinin subtype of the virus, the order being H2 > H6 ≥ H3 > H1 for Balb/c mice. H3 viruses are equally mitogenic for all strains of mice tested. In contrast, the mitogenic response to H2 and H6 viruses is controlled by the I-E subregion of the major histocompatibility complex. These viruses are mitogenic only for strains of mice that express surface I-E antigen (haplotypes a, d, k, p, r), and not for haplotypes b, f, q, s, which fail to synthesize a normal Eα chain and do not express surface I-E antigen. Mitogenesis by H2 and H6 viruses may involve direct interaction of virus with I-E molecules on the B lymphocyte or on an accessory cell, whereas mitogenesis by H3 viruses does not appear to involve I-E.
Url:
DOI: 10.1016/0264-410X(85)90115-X
Affiliations:
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Le document en format XML
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The magnitude of the proliferation induced varies with the haemagglutinin subtype of the virus, the order being H2 > H6 ≥ H3 > H1 for Balb/c mice. H3 viruses are equally mitogenic for all strains of mice tested. In contrast, the mitogenic response to H2 and H6 viruses is controlled by the I-E subregion of the major histocompatibility complex. These viruses are mitogenic only for strains of mice that express surface I-E antigen (haplotypes a, d, k, p, r), and not for haplotypes b, f, q, s, which fail to synthesize a normal Eα chain and do not express surface I-E antigen. Mitogenesis by H2 and H6 viruses may involve direct interaction of virus with I-E molecules on the B lymphocyte or on an accessory cell, whereas mitogenesis by H3 viruses does not appear to involve I-E.</div></front></TEI><affiliations><list><country><li>Australie</li></country><region><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Anders, E Margot" sort="Anders, E Margot" uniqKey="Anders E" first="E. Margot" last="Anders">E. Margot Anders</name></region><name sortKey="Scalzo, Anthony A" sort="Scalzo, Anthony A" uniqKey="Scalzo A" first="Anthony A." last="Scalzo">Anthony A. Scalzo</name><name sortKey="White, David O" sort="White, David O" uniqKey="White D" first="David O." last="White">David O. White</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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